Page 8 Heart Failure Remote Monitoring Evidence From the Retrospective Evaluation of a Real World Remote Monitoring Program

Source of Data

The primary source of data for this study is the RPDR. The detailed dataset from the RPDR contained
demographic and clinical information of patients including age, gender, race, diagnoses, hospital visits,
clinical notes, and vital status. All diagnoses were carefully verified in the electronic medical records to
limit misclassification of disease status due to data coding errors. We collected and reviewed all-cause

hospitalization and mortality data of CCCP patients and their corresponding controls starting from 120
days before enrollment in the CCCP program and up until 1 year after the CCCP enrollment date. The
study was approved by the Partners HealthCare Human Research Committee.

Outcome Measures

Outcomes were classified based on follow-up times. The primary outcomes were the effects of the
intervention assessed during the program duration of 4 months. The primary effects at 30 days, 60
days, 90 days, and at 4 months were on mortality and hospitalizations.

Secondary outcomes were the cumulative effects of the intervention assessed over a 1-year follow-up
period from the date of program enrollment, that is, following up participants for an additional follow-up

time of 8-months following program completion. The secondary effects evaluated were on mortality,
hospitalizations, risk for multiple hospitalizations, and length of hospital stay.

Statistical Analysis

Baseline data were summarized using descriptive statistics: means and standard deviation for
continuous data with normal distribution, medians for skewed data, and percentages for categorical
data. We examined group differences using the t test or the Wilcoxon-Mann-Whitney test for continuous
data and chi-square tests for categorical data. We also assessed baseline hospitalization rates 120 days

prior to CCCP enrollment to see if differences existed in hospitalization rates across both groups prior to
follow-up. Cumulative survival curves for time-to-event analyses were constructed by the Kaplan-Meier

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